The Efavirenz molecule - rotatable in 3 dimensions

Efavirenz is an antiretroviral medication, used to treat and prevent HIV/AIDS. It acts as an inhibitor of HIV's reverse transcriptase enzyme, which converts viral RNA into DNA, to be incorporated into human T lymphocyte cells.

It is described as a non-nucleoside reverse transcriptase inhibitor. NNRTIs act allosterically by binding to a distinct site away from the active site known as the NNRTI pocket.

It is a substituted benzoxazine compound and its molecular structure does not resemble DNA nucleosides which interact directly with the enzyme's active site.

Its chemical name is (S)-6-chloro-4-cyclopropylethynyl -4-trifluoromethyl -1,4-dihydro-benzo[d][1,3]oxazin-2-one

Efavirenz in combination with other drugs such as tenofovir/emtricitabine (Truvada) can be used as highly active antiretroviral therapy (HAART) treatments for HIV.

Label/ Unlabel atoms

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DNA bases