The Sulfamethoxazole molecule in 3-D

The Sulfamethoxazole molecule - rotatable in 3 dimensions

Sulfamethoxazole is an antibacterial or antimicrobial sulphonamide.

Members of this group act as an analogue of PABA (para-amino benzoic acid) and inhibit an enzyme that is involved in folate synthesis, thus starving the bacteria of the B-group vitamin folate. Trimethoprim inhibits a subsequent step in the reaction so it may act synergistically and sulfamethoxazole is often used in combination with trimethoprim (as co-trimoxazole).

It may be used against susceptible forms of Streptococcus, Staphylococcus aureus (including MRSA), Escherichia coli, Haemophilus influenzae, and oral anaerobes. It is commonly used to treat urinary tract infections

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