Coenzyme A is used in the transfer of acyl groups in carbohydrate and fatty acid metabolism.
There is a thiol (=SH) group
at one end of the Coenzyme A molecule, so it is sometimes referred to as CoASH. This can form thioesters
with the acyl groups
These groups - acetyl (CH3
COO-), succinyl (-
-COO-) - are 2-carbon and 4-carbon sections effectively derived from acetic (ethanoic) acid and succinic acid.
Do not confuse Acetyl Coenzyme A with the neurotransmitter substance Acetyl Choline
Acetyl Coenzyme A
is formed following the breakdown of pyruvate in the link reaction between glycolysis and the Krebs cycle, and
Succinyl Coenzyme A
is formed following the breakdown of α- ketoglutarate within the Krebs cycle itself.
The Coenzyme A molecule is built up from three sections: