Anti-Tuberculosis Drugs - each rotatable in 3 dimensions
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[isonicotinic acid hydrazide (INH)] is the current first line drug of choice for controlling tuberculosis.
It is used on its own for the control of latent tuberculosis and in combination with other drugs for active TB.
It works by inhibiting the formation of mycolic acid in the cell wall of Mycobacterium tuberculosis.
is also used for the control of active TB:
According to Zhang, Wade, Scorpio, Zhang and Sun , pyrazinoic acid, the active moiety of pyrazinamide, disrupts membrane energetics and inhibits membrane transport function in Mycobacterium tuberculosis.
(EMB) specifically inhibits the synthesis of arabinan in cell walls of Mycobacterium tuberculosis.
The molecule exists in 2 forms: The dextrorotatory (+) isomer is 500 times as active as the (-) isomer.